Antenatal is gravid and relevant serous albumen A detects
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A (pregnancy-associated Plasma Protein A of gravid and relevant serous albumen, PAPP-A) : PAPP-A, it is albumen of a macromolecule complex matter, generation at placenta.

25-44 of pair of pregnant woman age such as Zimmermann year old discover 1151 times when pregnant 10-13 Zhou Jin studies all right, 21 with the level of PAPP-A of serum of the mother's body with 18 3 fetal body under normal, it is respectively 0.51 with 0.08MoM. Clew PAPP-A can regard an independent serum as number other people.

Wald in 9 countries 21 obstetric centers undertake α of AFP, UE3, total HCG, dissociate to the pregnant woman of pregnant 8-14 week - β of HCG, dissociate - HCG, PAPP-A and restrain element A7 sieve of serum number other people is checked in, in all check gives 77 Tang family names to be asked for integratedly fetal. The PAPP-A that discovers sicken group is low when pregnant 8-14 week, pregnant 8-9 week is 0.36 MoM; Pregnant is 0.44MoM 10 weeks; Pregnant is 0.33MoM 11 weeks; Pregnant 12-4 week is 0.59MoM. Show PAPP-A also has the trend of heighten as gravid abidance. Wald thinks PAPP-A and free β - HCG is can distinguish Tang to be asked for integratedly most with normal and fetal serum number other people. Tang of 49% asks for PAPP-A of fetal matrix serum integratedly under 100 minutes of the 5th digit.

β of use PAPP-A, dissociate - the check that in pregnant 8-14 Zhou Shitang the family name asks for integratedly gives age of HCG union pregnant woman rate for 62% , false positive rate is 5% ; And the check when pregnant 15-22 week goes out rate for 59% .