The clinical meaning of hormone of chorion hurried sexual gland
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Hormone of chorion hurried sexual gland (HCG) : HCG is an accoucheur people be familiar with most the gravid experiment hormone that often uses. It is by α and β 2 get together the candy albumen composition of body. α inferior place of hormone of the leaf before the unit is hypophysis is mutual. β inferior the unit is HCG place is excellent. Complete HCG is by placenta the fit and alimentary layer of chorion arises entirely.
Think now, be transfer by alimentary layer model of cell and fit cell generation. Increase in before 8 gravid weeks very fast, in order to maintain gravid. After be in about 8 weeks, HCG drops gradually, till about 20 weeks when achieve relative stability. The HCG in pregnant woman serum basically exists with complete form, free β - the 1%-8% that HCG occupies total HCG.
HCG of serum of the matrix when Tang is asked for integratedly is elevatory, it is 2.11 MoM about. Family name of reportorial the Tang Dynasty asks for α of total when pregnant 8-14 week HCG, dissociate integratedly - HCG and free β - HCG, it is respectively 1.23, 0.86 with 1.79MoM. Jauniaux is opposite 58862 odd embryoes are inchoate and gravid undertake sifting checking, 13 Dovn are integrated there are 11 in asking for (the total HCG>;2.5 MoM of 84.6%) .
Noble is asked for integratedly to 76 Tang family names fetal it is normal to reach 800 fetal, determine when pregnant 10-14 week β of dissociate of serum of the mother's body - HCG chroma, family name of discovery the Tang Dynasty asks for β of fetal dissociate of serum of the mother's body integratedly - HCG chroma is remarkable prep above is normal (P<;0.0001) , sensitivity is 28.9% , false positive rate is 5% . The reason that Tang asks for HCG of fetal serum of the mother's body integratedly to lift is very not clear still.
The positive rate that the age of pregnant woman can affect a sieve to check and estimation check go out rate. In normal crowd AFP is 1.0 MoM, UE3 is 1.0 MoM, HCG is 1.0 MoM. In normal crowd, pregnant woman produces the dangerous sex that Tang asks for integratedly to be 1/1200, can make in 25 years old of crowds dangerous sex from normally 1/1200 falls to 1/4800; 35 years old person fall from 1/270 to 1/1080; 45 years old person fall from 1/20 to 1/80.
The AFP when Tang is asked for integratedly is 0.74 MoM, UE3 is 0.71 MoM, HCG is 2.11MoM. The dangerous sex that this numerical value expresses to with the happening related pregnant woman age Tang is asked for integratedly increased 4 times. Sex of the danger in crowd of 25 years old from normally occurence rate 1/1200 is added to 1/300; 35 years old person add from 1/270 to 1/72; 45 years old person add from 1/20 to 1/5.
In 25 years old of crowds, the positive rate that the sieve checks is 3.5% , check goes out rate for 46% ; 35 years old of crowds, the positive rate that the sieve checks is 13.5% , check goes out rate for 73% ; 45 years old of crowds, the positive rate that the sieve checks is 55% , check goes out rate for 98% .
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